We examine the impact of new medical information on drug safety on preventive health behavior. We exploit the release of the findings of the Women’s Health Initiative Study (WHIS) in 2002 – the largest randomized controlled trial of women’s health – which demonstrated that long-term Hormone Replacement Therapy increases the risk of heart attacks, stroke, blood clots and breast cancer among healthy post-menopausal women. Because hormone replacement is a therapy exclusive to women, we estimate the spillover effects of the WHIS findings on health behavior by means of a difference-in-differences methodology using men of similar ages as the control group. Using data from the Behavioral Risk Factor Surveillance System for 1997-2007, we find that women aged 60 and above started acting in unhealthier ways during the post-WHIS period as compared to men. This finding is consistent across a wide range of preventive health behavior and economically significant in magnitude, suggesting that policies aimed at raising awareness on the safety of medications may have unintended spillover effects on health behavior. Our results also indicate that the observed spillover effects of drug safety on health behavior were entirely driven by the less educated and that these spillovers may contribute to the existing health disparities by education.